약물의존증(藥物中毒, addiction substance dependency)은 사용된 약물에 심리적 또는 신체적 의존성을 보이는 증상을 말한다.정신질환 진단 및 통계 편람은 의존성을 1)몰입/갈구의 단계 2)만취/의존의 단계 3)금단 증세의 세 단계로 구분하였다. 약물의존증은 육체적 금단 현상이 사라져도 약물에 대한 강렬한 갈망을 느끼게 하며 결과적으로 계속적으로 약물을 사용하게 한다.
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↑Malenka RC, Nestler EJ, Hyman SE (2009). 〈Chapter 15: Reinforcement and Addictive Disorders〉. Sydor A, Brown RY. 《Molecular Neuropharmacology: A Foundation for Clinical Neuroscience》 2판. New York: McGraw-Hill Medical. 364–375쪽. ISBN9780071481274.
↑Nestler EJ (December 2013). “Cellular basis of memory for addiction”. 《Dialogues Clin. Neurosci.》 15 (4): 431–443. PMC3898681. PMID24459410. Despite the importance of numerous psychosocial factors, at its core, drug addiction involves a biological process: the ability of repeated exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and loss of control over drug use, that define a state of addiction. ... A large body of literature has demonstrated that such ΔFosB induction in D1-type [nucleus accumbens] neurons increases an animal's sensitivity to drug as well as natural rewards and promotes drug self-administration, presumably through a process of positive reinforcement ... Another ΔFosB target is cFos: as ΔFosB accumulates with repeated drug exposure it represses c-Fos and contributes to the molecular switch whereby ΔFosB is selectively induced in the chronic drug-treated state.41. ... Moreover, there is increasing evidence that, despite a range of genetic risks for addiction across the population, exposure to sufficiently high doses of a drug for long periods of time can transform someone who has relatively lower genetic loading into an addict.
↑“Glossary of Terms”. 《Mount Sinai School of Medicine》. Department of Neuroscience. 2015년 2월 9일에 확인함.
↑Volkow ND, Koob GF, McLellan AT (January 2016). “Neurobiologic Advances from the Brain Disease Model of Addiction”. 《N. Engl. J. Med.》 374 (4): 363–371. doi:10.1056/NEJMra1511480. PMID26816013. Substance-use disorder: A diagnostic term in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) referring to recurrent use of alcohol or other drugs that causes clinically and functionally significant impairment, such as health problems, disability, and failure to meet major responsibilities at work, school, or home. Depending on the level of severity, this disorder is classified as mild, moderate, or severe. Addiction: A term used to indicate the most severe, chronic stage of substance-use disorder, in which there is a substantial loss of self-control, as indicated by compulsive drug taking despite the desire to stop taking the drug. In the DSM-5, the term addiction is synonymous with the classification of severe substance-use disorder.