칼루메닌
칼루메닌(Calumenin)은 인간의 CALU 유전자에 의해 암호화되는 단백질이다.[1][2]
칼루메닌(CALU)은 소포체(ER)에 국한된 칼슘 결합 단백질이며 단백질 접힘 및 분류와 같은 소포체 기능에 관여한다. 칼루메닌은 CERC라는 소포체 및 골지체에서 EF 핸드 슈퍼 패밀리의 구성원이다. CERC는 Cab-45, reticulocalbin, Erc-55(RCN2), 칼루메닌 계열의 약자이다. CALU 유전자는 6개의 EF 핸드 모티프, 1개의 잠재적 N 글리코실화 부위 및 C 말단 소포체 체류 신호를 함유하는 315개의 아미노산 단백질을 암호화한다. 인간 및 쥐의 CALU 단백질은 98% 동일하다. CALU 전령 RNA는 인간 조직에서 편재적으로 발현되며 7q32에 맵핑된다.[2]
각주[편집]
- ↑ “Human calumenin gene (CALU): cDNA isolation and chromosomal mapping to 7q32”. 《Genomics》 49 (2): 331–3. Aug 1998. doi:10.1006/geno.1998.5245. PMID 9598325.
- ↑ 가 나 “Entrez Gene: CALU calumenin”.
추가 자료[편집]
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