3-아이소프로필말산 탈수소효소
3-아이소프로필말산 탈수소효소(영어: 3-isopropylmalate dehydrogenase) (EC 1.1.1.85)는 다음과 같은 화학 반응을 촉매하는 효소이다.[1][2][3][4]
- (2R,3S)-3-아이소프로필말산 + NAD+ ⇄ 4-메틸-2-옥소펜탄산 + CO2 + NADH
- (2R,3S)-3-아이소프로필말산 + NAD+ ⇄ (2S)-2-아이소프로필-3-옥소석신산 + H+ + NADH
- (2S)-2-아이소프로필-3-옥소석신산 + H+ ⇄ 4-메틸-2-옥소펜탄산 + CO2
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- ↑ Burns RO, Umbarger HE, Gross SR (1963). “The biosynthesis of leucine. III. The conversion of α-hydroxy-β-carboxyisocaproate to α-ketoisocaproate.”. 《Biochemistry》 2 (5): 1053–8. doi:10.1021/bi00905a024. PMID 14087358.
- ↑ Calvo JM, Stevens CM, Kalyanpur MG, Umbarger HE (December 1964). “The Absolute Configuration of α-carboxyisocaproic Acid (3-Isopropylmalic Acid), an Intermediate in Leucine Biosynthesis”. 《Biochemistry》 3 (12): 2024–7. doi:10.1021/bi00900a043. PMID 14269331.
- ↑ Parsons SJ, Burns RO (February 1969). “Purification and Properties of β-Isopropylmalate Dehydrogenase”. 《J. Biol. Chem.》 244 (3): 996–1003. PMID 4889950.
- ↑ Németh A, Svingor A, Pócsik M, Dobó J, Magyar C, Szilágyi A, Gál P, Závodszky P (February 2000). “Mirror image mutations reveal the significance of an intersubunit ion cluster in the stability of 3-isopropylmalate dehydrogenase”. 《FEBS Lett.》 468 (1): 48–52. doi:10.1016/S0014-5793(00)01190-X. PMID 10683439. S2CID 44544921.