SNAI1

SNAI1
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 2Y48, 3W5K, 4QLI
식별자
다른 이름	SNAI1, SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1, snail family zinc finger 1, snail family transcriptional repressor 1
외부 ID	OMIM: 604238 MGI: 98330 HomoloGene: 4363 GeneCards: SNAI1
유전자 위치 (인간) 염색체 20번 염색체 자리 20q13.13 시작 49,982,980 bp 끝 49,988,886 bp
유전자 위치 (쥐) 염색체 2번 염색체 (쥐) 자리 2 H3|2 87.33 cM 시작 167,380,115 bp 끝 167,384,734 bp
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 쓸개 왼자궁관 right lobe of thyroid gland left lobe of thyroid gland 상행대동맥 upper lobe of left lung 오른허파 왼관상동맥 오른관상동맥 right adrenal gland 최상위 발현 neural crest 중배엽 머리덮개뼈 태반 sclerotome 상실배 maxillary prominence 요막 tracheobronchial tree dermis 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 sequence-specific DNA binding DNA 결합 RNA polymerase II transcription regulatory region sequence-specific DNA binding 금속 이온 결합 kinase binding 단백질 결합 DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific E-box binding 세포 성분 세포핵 세포질 핵질 pericentric heterochromatin 세포액 생물학적 과정 trophoblast giant cell differentiation roof of mouth development regulation of bicellular tight junction assembly positive regulation of cell migration regulation of transcription by RNA polymerase II epithelial to mesenchymal transition involved in endocardial cushion formation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage multicellular organism development negative regulation of vitamin D biosynthetic process positive regulation of transcription, DNA-templated negative regulation of DNA damage response, signal transduction by p53 class mediator osteoblast differentiation negative regulation of cell differentiation involved in embryonic placenta development cartilage morphogenesis hair follicle morphogenesis left/right pattern formation mesoderm development negative regulation of transcription, DNA-templated cell migration negative regulation of transcription by RNA polymerase II Notch signaling involved in heart development mesoderm formation epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition heterochromatin organization aortic valve morphogenesis 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 6615 20613 앙상블 ENSG00000124216 ENSMUSG00000042821 유니프롯 O95863 Q02085 RefSeq (mRNA) NM_005985 NM_011427 RefSeq(단백질) NP_005976 NP_035557 위치(UCSC) Chr 20: 49.98 – 49.99 Mb Chr 2: 167.38 – 167.38 Mb PubMed 검색
위키데이터
인간 보기/편집 쥐 보기/편집

아연집게 단백질 SNAI1 (Zinc finger protein SNAI1)은 단백질로 SNAI1유전자에 의해 암호화되어있다.

기능

초파리 배아 단백질 SNAI1은 아연집게 전사 억제자로 중배엽내의 외배엽유전자의 발현을 하향 조절한다. 이 유전자에 의해 암호화 된 핵단백질은 구조적으로 초파리의 SNAI1 단백질과 유사하다. 그리고 발생하는 배아에 있어 중배엽의 형성에 매우 중요하다 생각된다. 2번 염색체의 최소한 두 가지의 변형된 위유전자가 발견되었다.

임상적 중요성

SNAI1 유전자는 E-캐드헤린의 CDH1유전자의 발현을 하향 조절하여 EMT(epithelial-mesenchymal transition)을 유발하여 유방암의 재발하게 함을 보여주었다.

상호작용

SNAI1은 CTDSPL과 CTDSP1과 CTDSP2과 함께 단백질 상호작용을 보여준다.

참고 자료

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